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Faculty of Arts and HumanitiesDean's Office, Faculty of Arts and HumanitiesJakobi 2, r 116-121 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of History and ArchaeologyJakobi 2 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Estonian and General LinguisticsJakobi 2, IV korrus 51005 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Philosophy and SemioticsJakobi 2, III korrus, ruumid 302-337 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Cultural ResearchÜlikooli 16 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of Foreign Languages and CulturesLossi 3 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Theology and Religious StudiesÜlikooli 18 50090 Tartu linn, Tartu linn, Tartumaa EST0Viljandi Culture AcademyPosti 1 71004 Viljandi linn, Viljandimaa EST0Professors emeritus, Faculty of Arts and Humanities0Associate Professors emeritus, Faculty of Arts and Humanities0Faculty of Social SciencesDean's Office, Faculty of Social SciencesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of EducationJakobi 5 51005 Tartu linn, Tartu linn, Tartumaa EST0Johan Skytte Institute of Political StudiesLossi 36, ruum 301 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Economics and Business AdministrationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of PsychologyNäituse 2 50409 Tartu linn, Tartu linn, Tartumaa EST0School of LawNäituse 20 - 324 50409 Tartu linn, Tartu linn, Tartumaa EST0Institute of Social StudiesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Narva CollegeRaekoja plats 2 20307 Narva linn, Ida-Virumaa EST0Pärnu CollegeRingi 35 80012 Pärnu linn, Pärnu linn, Pärnumaa EST0Professors emeritus, Faculty of Social Sciences0associate Professors emeritus, Faculty of Social Sciences0Faculty of MedicineDean's Office, Faculty of MedicineRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Biomedicine and Translational MedicineBiomeedikum, Ravila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of PharmacyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of DentistryL. Puusepa 1a 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Clinical MedicineL. Puusepa 8 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Family Medicine and Public HealthRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Sport Sciences and PhysiotherapyUjula 4 51008 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Medicine0associate Professors emeritus, Faculty of Medicine0Faculty of Science and TechnologyDean's Office, Faculty of Science and TechnologyVanemuise 46 - 208 51003 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Computer ScienceNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa ESTInstitute of GenomicsRiia 23b/2 51010 Tartu linn, Tartu linn, Tartumaa ESTEstonian Marine Institute0Institute of PhysicsInstitute of ChemistryRavila 14a 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Mathematics and StatisticsNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of Molecular and Cell BiologyRiia 23, 23b - 134 51010 Tartu linn, Tartu linn, Tartumaa ESTTartu ObservatoryObservatooriumi 1 61602 Tõravere alevik, Nõo vald, Tartumaa EST0Institute of TechnologyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Ecology and Earth SciencesJ. Liivi tn 2 50409 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Science and Technology0associate Professors emeritus, Faculty of Science and Technology0Area of Academic SecretaryHuman Resources OfficeÜlikooli 18, ruumid 302 ja 304 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of Head of FinanceFinance Office0Area of Director of AdministrationInformation Technology Office0Administrative OfficeÜlikooli 17 (III korrus) 51005 Tartu linn, Tartu linn, Tartumaa EST0Estates Office0Marketing and Communication OfficeÜlikooli 18, ruumid 102, 104, 209, 210 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of Vice Rector for DevelopmentCentre for Entrepreneurship and InnovationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0University of Tartu Natural History Museum and Botanical GardenVanemuise 46 51003 Tartu linn, Tartu linn, Tartumaa EST0International Cooperation and Protocol Office0University of Tartu MuseumLossi 25 51003 Tartu linn, Tartu linn, Tartumaa EST0Area of RectorRector's Strategy OfficeInternal Audit OfficeArea of Vice Rector for Academic AffairsOffice of Academic AffairsUniversity of Tartu Youth AcademyUppsala 10 51003 Tartu linn, Tartu linn, Tartumaa ESTStudent Union OfficeÜlikooli 18b 51005 Tartu linn, Tartu linn, Tartumaa EST0Centre for Learning and TeachingArea of Vice Rector for ResearchUniversity of Tartu LibraryW. Struve 1 50091 Tartu linn, Tartu linn, Tartumaa ESTGrant Office
Stem cell and cancer biology research group
cell cycle control
expression of pluripotency markers
tumor-associated signaling pathways in stem cells
pancreatic duct adenocarcinoma
p53
Human embryonic stem cells
Human embryonic stem (hES) cells are characterised by infinite proliferation and self-renewal capacity. In addition, hES cells are pluripotent, which means they can differentiate into almost every cell of the body. In our research we have focused on the control of their cell cycle and regulation mechanisms of pluripotency.
Another type of cells with infinite proliferation capacity are cancer cells. Previously we have focused on the tumour suppressor protein p53 in cancer cells. In the current project, we aim to uncover the role of aryl hydrocarbon receptor (AHR) in pancreatic ductal adenocarcinoma (PDAC). We test the hypothesis that inhibition of AHR activity with specific inhibitors has a potent therapeutic value in PDAC treatment. It is also important to mention that inhibition of AHR activity has great potential to boost the efficacy of cancer immunotherapy. Together with our project partners, we will develop and test novel AHR inhibitors in preclinical experiments.
Project: Inhibition of AHR signaling in pancreatic cancer to increase susceptibility to PD-1/PD-L1 inhibitors and chemotherapy via ELAVL1 pathway
Project donor: Baltic Research Cooperation Programme
Project timeline: 01.01.2021 - 31.12.2023
Project promoter: Lithuanian University of Health Sciences
More about the project, including the tasks and the overview of the meeting in Kaunas in October 2021.
1. Klepinina, L., Klepinin, A., Truu, L., Chekulayev, V., Vija, H., Kuus, K., Teino, I., Pook, M., Maimets, T. & Käämbre, T. (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLOS ONE, 16(1): e0245348. DOI: 10.1371/journal.pone.0245348
2. Teino, I., Matvere, A., Pook, Martin., Varik. I., Pajusaar, L., Uudeküll, K., Vaher, H., Trei, A., Kristjuhan, A., Org, T. & Maimets, T. (2020). Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation. Int. J. Mol. Sci. 21(23), 9052. DOI: 10.3390/ijms21239052
3. Matvere, A., Teino, I., Varik, I., Kuuse, S., Tiido, T., Kristjuhan, A., & Maimets, T. (2019). FSH/LH-Dependent Upregulation of Ahr in Murine Granulosa Cells Is Controlled by PKA Signaling and Involves Epigenetic Regulation. International Journal of Molecular Sciences, 20, 3068. DOI: 10.3390/ijms20123068
4. Ervin, E. H., Pook, M., Teino, I., Kasuk, V., Trei, A., Pooga, M., & Maimets, T. (2019). Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect. Stem Cell Research and Therapy, 10:43. DOI: 10.1186/s13287-019-1144-x
5. Ounpuu, L., Klepinin, A., Pook, M., Teino, I., Peet, N., Paju, K., Tepp, K., Chekulayev, V., Shevchuk, I., Koks, S., Maimets, T., & Kaambre, T. (2017). 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochimica et Biophysica Acta - General Subjects, 1861, 2146-2154. DOI: 10.1016/j.bbagen.2017.05.020
Awards of the Cultural Foundation of the President of the Republic given to Hedvig Tamman and Liisa Rätsep
Andres Metspalu elected member of Academia Europaea
